Pipeline

Cardiac Muscle Contractility

ProductPreclinicalPhase IPhase IIPhase IIIStatus
   
High Risk Heart Failure:
    
 
Safety and Efficacy (oral)
   
Phase IIb planning is underway (1)
Safety and Efficacy (iv)
   
Phase IIb planning is underway (1)
Stable Heart Failure:
    
 
Pharmacokinetic (MR/IR - oral)
   
Phase IIa planning underway (1)
Safety and Tolerability (iv)
   
Phase II completed in Q1 09
Ischemic Cardiomyopathy (iv/oral)
   
Phase II completed in 2008
Healthy Volunteers:
    
 
Drug/Drug Interaction (oral)
   
Phase I completed in 2008
Single-Dose to Multi-Dose (oral)
   
Phase I completed in 2008
Oral Modified Release (oral)
   
Phase I completed in 2008
Safety and Tolerability (iv)
   
Phase I completed in 2006
Renal Dysfunction:
    
 
Pharmacokinetic (MR - oral)
   
Phase I planning is underway (1)

Skeletal Muscle Contractility

ProductPreclinicalPhase IPhase IIPhase IIIStatus
   
ALS
   
Phase IIa EOE (Evidence of Effect trial) initiated in Q1 2010
Intermittent Claudication
   
Phase IIa EOE initiated in Q2 2010
      
   
IND-enabling studies ongoing

Smooth Muscle Contractility

ProductPreclinicalPhase IPhase IIPhase IIIStatus
   
Preclinical development ongoing

Oncology

ProductPreclinicalPhase IPhase IIPhase IIIStatus
   
Breast Cancer
   
Data presented at ASCO 2009
      
   
Hodgkin/Non-Hodgkin Lymphoma
   
Data presented at ASH 2010
      
   
Advanced Solid Tumors
   
Data presented at ASCO 2010

Current status as of 7/10

(1) Sponsored by Amgen

Cytokinetics Program Status Program Status
Cytokinetics Completed Clinical Trial Completed Clinical Trial
Cytokinetics Ongoing Clinical Trial Ongoing Clinical Trial
Cytokinetics Program Status Planned Activity