Scientific and Medical Publications
Viewing these files requires the Adobe Acrobat Reader® Cardiovascular | Oncology | Other Shen Y, Zhang Y, Morgans DJ, Vatner SF, Malik F. A Novel Inotropic Agent That Activates Cardiac Myosin and Increases Cardiac Contractility Without Increasing MVO2 in Heart Failure with Left Ventricular Hypertrophy. American College of Cardiology Conference, Chicago, IL. March, 2008. Poster presentation Anderson RL, Pokrovskii M, Suekawa K, Rodriguez HM, Elias, KA. The Cardiac Myosin Activator CK-1827452-Induced Myocyte Contractility is Unchanged in the Presence of β-Blockade. 2007 American Society of Cell Biology (ASCB) Conference, Washington, DC. December, 2007. Poster presentation Jerling M, Chew T, Escandon R, Lee J, Saikali K, Venables E, Clarke C, Malik F, Wolff A. Oral Bioavailability of the Selective Cardiac Myosin Activator CK-1827452: Chronic Oral Inotropic Therapy for Heart Failure. 2007 Annual Heart Failure Society of America Meeting, Washington, DC. September, 2007. Poster presentation Malik FI, Saikali KG, Clarke CP, Teerlink JR, Wolff AA. Systolic Ejection Time is a Sensitive Indicator of Left Ventricular Systolic Function During Treatment with the Selective Cardiac Myosin Activator, CK-1827452. 2007 Annual Heart Failure Society of America Meeting, Washington, DC. September, 2007. Poster presentation Anderson R, Pokrovskii M, Elias K. Effects of Cardiac Myosin Activators on Excitation-Contraction (E-C) Coupling in Ventricular Myocytes. Biophysical Society 51st Annual Meeting, Baltimore, MD. March, 2007. Poster presentation Rodriguez H, Kawas R, Malik F, Sakowicz R, Hartman J. The Cardiac Myosin Activator, CK-1827452, Accelerates the Enzymatic Step Gating Entry of Myosin into its Force Generating State. Biophysical Society 51st Annual Meeting, Baltimore, MD. March, 2007. Poster presentation Anderson RL, Pokrovskii M, Elias KA. Effects of the Cardiac Myosin Activator CK-1316719 on Excitation-Contraction (E-C) Coupling in Ventricular Myocytes. 46th Annual American Society for Cell Biology Meeting, San Diego, CA. December, 2006. Poster presentation Baliga R, Rodriguez HM, Guo D, Hartman JJ, Pierce DW, Sakowicz R, Morgan BP, Malik F, Finer JT. A Sensitive Assay for the Basal Atpase Activity of Cardiac Myosin. Society of Biomolecular Sciences Annual Meeting, Seattle (September 2006). Poster presentation Anderson RL, Kawas RF, Pokrovskii MV, Godinez G, Lee KH, Mak J, Hartman JJ, Morgan BP, Morgans Jr., DJ, Malik F, Sakowicz R, Elias KA. Cardiac Myosin Activator CK-1316719 Increases Myofibril ATPase Activity and Myocyte Contractility in a Rat Model of Heart Failure. Heart Failure Society of America (HFSA), September, 2006. Poster presentation Shen YT, Vatner SF, Morgans DJ, Malik F. Activating Cardiac Myosin, a Novel Inotropic Mechanism to Improve Cardiac Function in Conscious Dogs with Congestive Heart Failure. Heart Failure Society of America (HFSA), September, 2006. Poster presentation Anderson RL, Sueoka SH, Lee KH, Rodriguez HM, Kawas R, Godinez G, Morgan BP, Sakowicz R, Morgans Jr, DJ, Malik F, Elias KA. In Vitro and In Vivo Characterization CK-1827452, a Selective Cardiac Myosin Activator. Heart Failure Society of America (HFSA), September, 2006. Poster presentation Rodriguez HM, Sylvester S, Kawas R, Malik F, Sakowicz R. Activation of the Cardiac Sarcomere by a Small Molecule Agent, CK-1213296. Biophysical Society Annual Meeting. February, 2006. Poster presentation Rodriguez HM, Sylvester S, Hartman J, Shen YT, Kass DA, Vatner SF, Malik F, Sakowicz R. A Detailed Kinetic Analysis of the Cardiac Myosin Activator, CK-1213296, Suggests It Improves Cardiac Contractility by Accelerating Transition from the Weak to Strongly Bound States. Molecular Mechanisms of Cardiac Disease and Regeneration. February, 2006. Poster presentation Lenzi D, Fritsch A, Alexander G, Hansen R, Cong G, Zink W, Godinez G, Pham A, Trautman J, Pierce DW, Malik F, Finer JT. A Multiplexed and Automated Imaging Assay of Cardiac Myocyte Contractility. American Society of Cell Biology (ASCB) December, 2005. Poster presentation Anderson RL, Sueoka SH, Rodriguez HM, Lee KH, Cox DR, Kawas R, Morgan BP, Sakowicz R, Morgans Jr DJ, Malik F, Elias KA. In Vitro and In Vivo Efficacy of the Cardiac Myosin Activator CK-1827452. American Society of Cell Biology (ASCB) December, 2005. Poster presentation Malik F, Elias KA, Finer JT, Morgan BP, Sakowicz R, Anderson R, Baliga R, Conn L, Cox D, Garard M, Hartman J, Irvine J, Kawas R, Kraynack E, Kuklov A, Lee KH, Lu P, Muci A, Pierce DW, Rodriguez H, Suehiro I, Sueoka SH, Sylvester S, Tochimoto T, Valdez C, Wang W, Katori T, Kass DA, Shen YT, Vatner SF, and Morgans DJ . Direct Activation of Cardiac Myosin by CK-1827452 Improves Cardiac Function in a Dog Heart Failure Model. Heart Failure Society of America Meeting, September 2005. Poster presentation Malik F, Shen Y, Katori T, Sueoka SH, Anderson R, Cox D, Garard M, Hartman J, Kim S, Kraynack E, Kuklov A, Lee KH, Lu P, Muci A, Niu C, Rodriguez H, Suehiro I, Sylvester S, Tochimoto T, Elias KA, Morgan BP, Sakowicz R, Kass DA, Vatner SF, Morgans DJ. Direct Activation of Cardiac Myosin, A Novel Mechanism for Improving Cardiac Function. American Heart Association (AHA) Keystone, July 2005. Poster presentation Anderson R, Niu C, Elias K. The Cardiac Myosin Activator, CK-1122534, Overcomes the Myosin II Inhibitors 2, 3-Butanedione-2-Monoxime and (-)-S-Blebbistatin without Affecting the Ca2+ Transient in Ventricular Myocytes. American Society of Cell Biology, December 2004. Poster presentation Niu C, Anderson R, Cox D, Qian X, Morgan B, Malik F, Morgans Jr D, Elias K. The Cardiac Myosin Activator, CK-1122534, Increases Contractility in Adult Cardiac Myocytes without Altering the Calcium Transient. American Society of Cell Biology, December 2004. Poster presentation Niu C, Cox D, Lee K, Sylvester S, Sueoka S, Qian X, Feng B, Malik F, Morgans Jr D, Hartman J, Sakowicz R, Elias K. Cellular Responses of the Myosin Activator CK-0689705 in Normal and Heart Failure Models. American Society of Cell Biology, December 2004. Poster presentation Rodriguez H, Sylvester S, Qian X, Morgan B, Morgans Jr D, Malik F, Sakowicz R. Activation of Cardiac Sarcomere ATPase by CK-1122534, a Small Molecule Agent that Specifically Targets Cardiac Myosin. American Society of Cell Biology, December 2004. Poster presentation Rodriguez H, Sylvester S, Sakowicz R. Interaction of Myosin with Blebbistatin Reported by Fluorescence Spectroscopy. American Society of Cell Biology, December 2004. Poster presentation Niu C, Anderson RL, Cox DR, Morgan BP, Morgans Jr DJ, Malik F, Elias KA. The Cardiac Myosin Activator, CK1122534, Increases Contractility in Adult Cardiac Myocytes But Does Not Affect the Transient or Depend on Second Messenger Signaling. American Heart Association, November 2004. Poster presentation Spudich JA. O'Connor OA, Goy A, Orlowski RZ, Hainsworth J, Leonard JP, Afanasyev B, Osmanov D, Reyno L, Chen MM, Escandon R. A Phase I-II Study to Determine the Safety, Pharmacokinetics and Potential Efficacy of the Kinesin Spindle Protein (KSP) Inhibitor SB-743921 on Days 1 and 15 of a 28 Day Schedule in Patients with Non-Hodgkin’s or Hodgkin’s Lymphoma. 49th American Society of Hematology Annual Meeting, Atlanta GA. December 2007. Poster presentation Chua PR, Desai R, Schauer SP, Cornwell W, Gilmartin A, Sutton D, Wood KW. Differential Response of Tumor Cell Lines to Inhibition of the Mitotic Checkpoint Regulator and Mitotic Kinesin, CENP-E. AACR-NCI-EORTC International Conference on Molecular Targets and Cancer, San Francisco CA. October 2007. Poster presentation Sutton D, Gilmartin AG, Kusnierz AM, Sung CM, Luo L, Carson JD, Laquerre SG, Cornwell W, King AG, Knight SD, Dhanak D, Bergnes G, Qian X, Chua P, Wood KW, Huang PS, Weber BL, Copeland RA, Jackson JR. A Potent and Selective Inhibitor of the Mitotic Kinesin CENP-E (GSK923295A) Demonstrates a Novel Mechanism of Inhibiting Tumor Cell Proliferation and Shows Activity Against a Broad Panel of Human Tumor Cell Lines in vitro. AACR-NCI-EORTC International Conference on Molecular Targets and Cancer, San Francisco CA. October 2007. Poster presentation Shahin M, Braly P, Rose P, Malpass T, Bailey H, Alvarez RD, Hodge J, Bowen C, Buller R. A Phase II, Open-Label Study of Ispinesib (SB-715992) in Patients with Platinum/Taxane Refractory or Resistant Relapsed Ovarian Cancer. American Society of Clinical Oncology, Chicago, IL. June, 2007. Poster presentation Chen Q, Pamarthi V, Kuhn D, Voorhees P, Strader J, Orlowski R. Inhibition of Kinesin Spindle Protein Induces Apoptosis and Overcomes Drug Resistance in Models of Multiple Myeloma. Annual Meeting of the American Association for Cancer Research (AACR), Los Angeles, CA. April, 2007. Poster presentation Sutton D, Diamond M, Faucette L, Giardiniere M, Zhang S, Vidal J, Dhanak D, Knight S, Bergnes G, Qian X, Wood K, Morgans D, Huang P, Jackson J. GSK-923295, a Potent and Selective CENP-E Inhibitor, Has Broad Spectrum Activity Against Human Tumor Xenografts in Nude Mice. Annual Meeting of the American Association for Cancer Research (AACR), Los Angeles, CA. April, 2007. Poster presentation Lad L, Luo L, Wood K, Hartman J, Copeland R, Sakowicz R. Detailed Biochemical Analysis of the CENP-E Inhibitor GSK-923295. Annual Meeting of the American Association for Cancer Research (AACR), Los Angeles, CA. April, 2007. Poster presentation Roof D, Bergnes G, Wang J, Yang Z, Ashcraft L, Collibee S, Ramchandani S, Fan J, Desai R, Moon-Crompton A, Xu D, Morgan B, Keon B, Vacin C, Lila T, Vaisberg E, De Hostos E, Chua P, Purcell J, Trautman J, Morgans D, Wood K, Adams C. Cell-based Discovery and Anti-tumor Activity of a Novel Mitotic Inhibitor. Annual Meeting of the American Association for Cancer Research (AACR), Los Angeles, CA. April, 2007. Poster presentation Ramchandani S, Schauer S, Adams C, de la Rosa R, Freedman R, Mak J, Beraud C, Lee Y, Sakowicz R, Wood K, Belmont L. Functional Studies of Human Kip3D (Kif18a) Kinesin. 46th Annual American Society for Cell Biology Meeting, San Diego, CA. December, 2006. Poster presentation Guo D, Baliga R, Pierce DW, Belmont L, Finer JT. A Novel Mechanism for Kinesin Spindle Protein (KSP) Modulation: Small Molecular Activators of KSP Basal ATPase. 46th Annual American Society for Cell Biology Meeting, San Dieago, CA. December, 2006. Poster presentation de Hostos RL, Lee Y, Sakowicz R, Belmont L. Characterization of Motor=Domain Mutants of the Mitotic Kinesin RAB6KIFL (MKLP2, KIF20A). 46th Annual American Society for Cell Biology Meeting, San Diego, CA. December, 2006. Poster presentation Chen Q, Pamarthi V, Kuhn DJ, Voorhees PM, Strader JS, Orlowski RZ. Inhibition of Kinesin Spindle Protein Induces Apoptosis and Overcomes Drug Resistance in Models of Multiple Myeloma. December, 2006. Poster presentation Houghton PJ, Maris JM, Friedman HS, Keir ST, Lock RB, Gorlick R, Kolb EA, Reynolds CP, Morton C, Smith MA,. Pediatric Preclinical Testing Program (PPTP) Evaluation of the KSP Inhibitor Ispinesib (SB-715992). 18th EORTC-NCI-AACR Symposium on "Molecular Targets and Cancer Therapeutics," Prague, Czech Republic. November 2006. Poster presentation Belmont LD, Sutton D, Wood KW. Sequence dependent anti-tumor activity of bortezomib and the KSP inhibitor, SB-743921, in a solid tumor xenograft model. 18th Annual EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, Prague, Czech Republic . November, 2006. Poster presentation Rodon J, E. Till, Patnaik A, Takimot C, Kathmanz S, Williams D, Vasist L, Bowen C, Hodge J, Dar M, Tolcher A. Phase I Study of lspinesib in Combination with Capecitabine in Patients with Advanced Solid Tumors. 18th Annual EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, Prague, Czech Republic . November, 2006. Poster presentation Tang PA, Siu LL, Chen EX, Hotte SJ, Chia S, Schwarz JK, Colevas AD, Johnson C, Pond GR, Winquist E. A Phase II study of ispinesib in patients with recurrent and/or metastatic head and neck squamous cell carcinoma. 31st ESMO Congress, Istanbul, Turkey. September, 2006. Poster presentation Jackson JR, Gilmartin A, Dhanak D, Knight S, Luo L, Sutton D, Caulder E, Diamond M, Giardiniere M, Zhang S, Huang P;. A second generation KSP inhibitor, SB-743921, is a highly potent and effective therapeutic in preclinical models of cancer. AACR Molecular Diagnostics in Cancer Therapeutics Conference, Chicago, IL. September, 2006. Poster presentation E.I. Heath, A. Alousi, J.P.Eder, M. Valdivieso, L.S. Vasist, L. Appleman, P. Bhargava, A.D.Colevas, P.M.LoRusso, G. Shapiro. A Phase I Dose Escalation Trial of Ispinesib (SB-715992) Administered Days 1-3 of a 21-day Cycle in Patients with Advanced Solid Tumors. American Society of Clinical Oncology (ASCO), June, 2006. Poster presentation S. F. Jones, E.R. Plummer, H. A. Burris III, A Razak, A. Meluch, C.J. Bowen, D.D. Williams, L.S. Vasist, J.P. Hodge, M.M. Dar, A.H. Calvert. Phase I Study of Ispinesib in Combination with Carboplatin in Patients with Advanced Solid Tumors. American Society of Clinical Oncology (ASCO), June, 2006. Poster presentation A.B. El-Khoueiry, S. Iqbal, D.A. Singh, S. D’Andre, R.K. Ramanathan, S. Shibata, D. Y. Yang, H.J. Lenz, T. Synold, D.R. Gandara. A Randomized Phase II Non-Comparative Study of Ispinesib Given Weekly or Every Three weeks in Metastatic Colorectal Cancer. A California Cancer Consortium Study (CCC-P). American Society of Clinical Oncology (ASCO), June, 2006. Poster presentation Miller K, Ng C, Ang P, Brufsky AM, Lee SC, Dees EC, Piccart M, Verrill M, Wardley A, Loftiss J, Bal J, Yeoh S, Hodge J, Williams D, Dar M, Kathman S, and Ho PT C. Phase II, Open Label Study of Ispinesib in Patients with Locally Advanced or Metastatic Breast Cancer. San Antonio Breast Cancer Symposium (SABCS), December, 2005. Poster presentation Sutton D, Zhang SY, Gilmartin A, Wood KW, Jackson JR, Huang P. Mitotic Arrest in Tumors as a Pharmacodynamic Marker for Inhibition of the Mitotic Kinesin KSP by Ispinesib, a novel KSP inhibitor. AACR-NCI-EORTC, November 2005. Poster presentation Jackson JR, Auger KR, Gilmartin A, Eng WK, Luo L, Concha N, Parrish C, Sutton D, Diamond M, Giardiniere M, Zhang SY, Huang P. A Resistance Mechanism for the KSP Inhibitor Ispinesib Implicates Point Mutations in the Compound Binding Site. AACR-NCI-EORTC, November 2005. Poster presentation Sutton D, Diamond M, Onori J, Zhang SY, Giardiniere M, Faucette L, Belmont L, Wood KW, Jackson JR, Huang P. Cisplatin Enhances the Activity of Ispinesib, a Novel KSP Inhibitor, Against Murine P388 Lymphocytic Leukemia. AACR-NCI-EORTC, November 2005. Poster presentation Sutton D, Zhang SY, Diamond M, Giardiniere M, Faucette L, King AG, Chen YJ, Wood KW, Jackson JR, Huang P. Relationship Between the Antitumor Activity of Ispinesib, a Novel KSP Inhibitor, and Neutropenia in a Human Xenograft Model. AACR-NCI-EORTC, November 2005. Poster presentation Blagden S, Seebaran G, Molife1 R, Payne M, Reid1 A, Protheroe A, Kathman S, Williams D, Bowen C, Hodge J, DarM, de Bono1 J, Middleton M. Phase I Study Of Ispinesib In Combination With Docetaxel in Patients With Advanced Solid Tumors. AACR-NCI-EORTC, November 2005. Poster presentation Calvo E, Chu Q, Til E, Rowinsky E, Patnaik A, Takimoto C, Kathman S, Williams D, Bowen C, Hodge J, Dar M, Tolcher A. Phase I Study Of Ispinesib In Combination With Capecitabine in Patients With Advanced Solid Tumors. AACR-NCI-EORTC, November 2005. Poster presentation Holen KD, Belan CP, Wilding G, Ramalingam S, Volkman1 JL, Ramanathan RK, Bowen CJ, Williams DD, Hodge JP, Dar MM, Ho PTC. Phase I Study to Determine Tolerability & Pharmacokinetics (PK) of SB-743921, a Novel Kinesin Spindle Protein (KSP) Inhibitor. American Society of Clinical Oncology (ASCO), May 2005. Poster presentation Brejc K, Yu M, Lee Y, Belmont L, Hartman J, Guo J, Lichtsteiner S, Wood K, Sakowicz R. Structure of Human Kip3d – Unconventional Microtubule Depolymerizing Kinesin. American Society of Cell Biology (ASCB), December 2004. Poster presentation Williams DD, Kathman SJ, Chu QSC, Holen KD, Rowinsky EK, Wilding G, Mudd Jr PN, Herendeen JM, Orr JB, Pandite LN. A Phase I Study (KSP10001) of SB-715992, a Novel Kinesin Protein Spindle (KSP) Inhibitor: Pharmacokinetic (PK)/ Pharmacodynamic (PD) Modeling of Absolute Neutrophil Counts (ANC). EORTC-NCI-AACR, September 2004. Poster presentation Chu Q, Holen KD, Rowinsky EK, Wilding G, Volkman JL, Orr JB, Williams DD, Hodge JP, Kerfoot CA, Sabry J. A Phase I Trial of Novel Kinesin Spindle Protein (KSP) Inhibitor, SB-715992 Administered Intravenously Once Every 21 Days. American Society of Clinical Oncology (ASCO), June 2004. Poster presentation Sakowicz R, Finer JT, Beraud, Crompton A, Lewis E, Fritsch A, Lee Y, Mak J, Moody R, Turincio R, Chabala JC, Gonzales P, Roth S, Weitman S, Wood KW. Antitumor Activity of a Kinesin Inhibitor Chu Q, Holen KD, Rowinsky EK, Alberti DB, Monroe P, Volkam JL, Hodge JP, Bush P, Pandite L, Williams D, Hoke F, Sabry J, HO PTC, Wilding G. A Phase I Study to Determine the Safety and Pharmacokinetics of IV Administered SB-715992, A Novel Kinesin Spindle Protein (KSP) Inhibitor, in Patients with Solid Tumors. American Society of Clinical Oncology (ASCO). May 2003. Poster presentation Hedge P, Cogswell J, Carrick K, Jackson JR, Wood KW, Eng WK, Brawner M, Huang PS, Gergsma D. Differential Gene Expression Analysis of Kinesin Spindle Protein in Human Solid Tumors. American Society of Clinical Oncology (ASCO). May 2003. Poster presentation LoRusso JB, Jones JB, Gadgeel1 S, Willcutt N, Helmke1 W, Orr J, Hodge J, Williams D, Pandite L, Sabry J, Ho P, Burris III H. A Phase I Study To Determine the Safety and Pharmacokinetics of Intravenous Administration of SB-715992, a Novel Kinesin Spindle Protein (KSP) Inhibitor, on a Once Weekly for Three Consecutive Weeks Schedule in Patients With Refractory Solid Tumors. European Cancer Conference (ECCO), September 2003. Poster presentation Mak J, Freedman R, Beraud C. Utilization of Gene Expression Profiles to Identify Mitotic Kinesins. American Association for Cancer Research (AACR). April 2002. Poster presentation Bergnes G, Ha E, Feng B, Yao B, Smith WW, Tochimoto T, Lewis ER, Lee YY, Moody R, Turincio RA, Finer JT, Wood KW, Sakowicz R, Crompton AM, Chabala JC, Morgans Jr DJ, Sigal NH, Sabry JH. Mitotic Kinesin-Targeted Antitumor Agents: Discovery, Lead Optimization and Anti-Tumor Activity of a Series of Novel Quinazolinones as Inhibitors of Kinesin Spindle Protein (KSP). American Association for Cancer Research (AACR), April 2002. Poster presentation Gonzales P, Bienek A, Boehme M, Rivali C, Roth S, Wynne H, Piazza G, Weitman S, Wood K, Crompton A, Moody R, Schauer S, Feng B, Bergnes G, Sigal N, Morgans D. Breadth of Anti-tumor Activity of CK0238273 (SB-715992), a Novel Inhibitor of the Mitotic Kinesin KSP. American Association for Cancer Research (AACR), April 2002. Poster presentation Jackson JR, Gilmartin AG, Williams T, McCabe FL, Caulder E, Inlow L, Whitacre M, Mattern M, Bergnes G, Feng B, Smith WW, Morgans D, Ward K, Smith B, Wood KW, Moody RS, Belmont L, Schauer S, Johnson RK, Winkler JD. A Pharmacodynamic Marker of Mitosis Demonstrates the Anti-mitotic Activity of SB-715992, an Inhibitor of the Mitotic Kinesin KSP. American Association for Cancer Research (AACR), April 2002. Poster presentation Johnson RK, McCabe FL, Cauder E, Innlow L, Whitacre M, Winkler JD, Bergnes G, Feng B, Smith WW, Morgans D, Wood K, Jackson JR. SB-715992, a Potent and Selective Inhibitor of KSP Mitotic Kinesin, Demonstrates Broad-spectrum Activity in Advanced Murine Tumors and Human Tumor Xenografts. American Association for Cancer Research (AACR), April 2002. Poster presentation Lee Y, Ji Z, Sakowicz R. Inhibitors of the Mitotic Kinesin KSP: Biochemical Mechanism of Action. American Association for Cancer Research (AACR), April 2002. Poster presentation Wood KW, Cornwell WD, Jackson JR. Turner J, Anderson R, Guo J, Beraud C, Fletterick R, Sakowicz R. Sakowicz R, Berdelis MS, Ray K, Blackburn CL, Hopmann C, Faulkner DJ, Goldstein LS. Sablin EP, Kull FJ, Cooke R, Vale RD, Fletterick RJ. Lila T, Chua PR, Vacin C, Collibee S, Clarke D, Roof D, Morgan BP, Maxon ME, Pierce DW, Finer JT. Image-Based Identification of Small-Molecule Inhibitors of Yeast Pathogen Morphogenesis. American Society of Cell Biology (ASCB) December, 2005. Poster presentation Baliga R, Guo D, Chua PR, Stephens T, Yu M, Pierce DW, Sakowicz R, Lichtsteiner S, Maxon ME, Finer JT. Microtubule Depolymerization Activity of a Kip3 Kinesin: Results from a Novel High-Throughput Microtubule Depolymerization Assay. American Society of Cell Biology (ASCB) December, 2005. Poster presentation Tomasevic N, Russell A, Pierce DW, Jia Z, Sakowicz R. Identification and Biochemical Characterization of Small Molecule Arp2/3 Complex Inhibitors. American Society of Cell Biology (ASCB) December, 2005. Poster presentation Baliga R, Guo D, Tomasevic N, Jia Z, de Hostos E , Brejc K, Sakowicz R, Lichtsteiner S, Pierce SW, Finer JT. A Comparison of Two High-Throughput Assays for FtsZ Inhibitors. American Society of Cell Biology (ASCB) December, 2005. Poster presentation Tanaka M, Bateman R, Rauh D, Vaisberg E, Ramachandani S, Zhang C, Hansen KC, Burlingame AL, Trautman JK, Shokat KV, Adams CL. An Unbiased Cell Morphology-Based Screen for New, Biologically Active Small Molecules. PLOS Biology, May 2005. Baliga R, Guo D, Yu M, Hekmat-Nejad M, Sakowicz R, Pierce D, Finer J. A High Throughput Screen for Inhibitors of Microtubule Depolymerizing Enzyme from Plasmodium Falciparum. American Society of Cell Biology (ASCB), December 2004. Poster presentation Hekmat-Nejad M, Sakowicz R. Regulation of Atpase Activity of Internal Motor Kinesin, pKinI: Binding to Microtubule Lattice is Non-Productive. American Society of Cell Biology (ASCB), December 2004. Poster presentation Tomasevic N, Chua P, Jia Z, Speer J, Stephens T, Hartman J, Suekawa K, Freedman R, Maxon M, Sakowicz R. Identification and Characterization of Candida Albicans Formins. American Society of Cell Biology (ASCB), December 2004. Poster presentation Tomasevic N, Jia Z, Russell A, Fujii T, Hartman J, Clancy S, Beraud C, Wang M, Wood K, Sakowic R. Regulation of WASP and N-WASP by Different Activators. American Society of Cell Biology,(ASCB), December 2004. Poster presentation Tomasevic N, Jia Z, Speer J, Wang M, Belmont L, Hartman J, Sakowicz R. Vasodilator-Stimulated Phosphoprotein (VASP) Promotes Arp2/3 Complex Mediated Actin Polymerization, Prevents Branching and Stabilizes Actin Filaments. American Society of Cell Biology (ASCB), December 2004. Poster presentation Vale RD, Milligan RA. Kull FJ, Sablin E, Lau R, Fletterick RJ, Vale RD. |