Cytokinetics is dedicated to the discovery, development and commercialization of novel classes of small molecule therapeutics. To date, our drug candidates and potential drug candidates have all arisen from our leadership position in the emerging field of cytoskeletal pharmacology. The cytoskeleton is a complex, dynamic framework of proteins that is essential for many aspects of cell function including cell division, cell motility, intracellular transport, muscle contractility and regulation of cellular organization. Each of our drug discovery programs begins with a defined therapeutic hypothesis that focuses on the etiology or pathophysiology of the disease of interest. These therapeutic hypotheses are informed by either having already been validated by existing pharmaceuticals that target a cytoskeletal protein that play an important role in the treatment of the disease or by genetic mutations in a cytoskeletal protein gives rise to the disease. |